COMPORTAMIENTO ANTIARRÍTMICO DE LA HIPOXIA EN SIMULACIONES DE PARED TRANSMURAL CARDÍACA EN PRESENCIA DE ISQUEMIA SUB-EPICÁRDICA
Palabras clave:
Electrogramas, hipoxia, isquemia, modelo Luo-Rudy, pared transmural heterogénea, reentrada espiral, taquicardia ventricular polimórfica, Electrograms, heterogeneous transmural wall, hypoxia, ischemia, Luo-Rudy model, polymorphic ventricular tachycardiaResumen
RESUMEN
El papel preponderante de la corriente de potasio sensitiva a Adenosin Trifosfato y su contribución a cambios electrofi siológicos que ocurren durante heterogeneidades y alteraciones fisicoquímicas debido a isquemia en la pared transmural cardíaca son aún debatidos. El objetivo de este trabajo fue estudiar la infl uencia de la activación de la hipoxia en la desestabilización del frente de onda eléctrico en pared transmural heterogénea en presencia de isquemia subepicárdica en un modelo computacional de tejido virtual. La taquicardia polimórfi ca obtenida de las simulaciones muestra que la activación de la hipoxia presenta un comportamiento antiarrítmico. La hiperkalemia es el principal agente capaz de generar bloqueo de conducción y alteraciones del segmento TQ y el segmento ST en los electrogramas obtenidos.
Palabras clave: Electrogramas, hipoxia, isquemia, modelo Luo-Rudy, pared transmural heterogénea, reentrada espiral, taquicardia ventricular polimórfica.
ABSTRACT
ANTIARRHYTHMIC BEHAVIOR OF HYPOXIA IN CARDIAC TRANSMURAL WALL SIMULATIONS IN PRESENCE OF SUB-EPICARDIC ISCHEMIA
The role of potassium adenosine triphosphate sensitive fl ow and its contributions to electrophysiological changes that occur during chemical-physical alterations and heterogeneities due to ischemia in cardiac transmural wall is still debated.
The aim of this work was to study hypoxia activation influence in wavefront electric disturbance in heterogeneous transmural wall subjected to sub-epicardial ischemia, using a virtual tissue computational model. Polymorphic tachycardia obtained of simulations show hypoxic activation anti-arrhythmic behavior. Hiperkalemia is the main agent able to block heart conduction, TQ segment and ST segment alterations of calculated electrograms.
Keywords: Electrograms, heterogeneous transmural wall, hypoxia, ischemia, Luo-Rudy model, polymorphic ventricular tachycardia, spiral reentry
Biografía del autor/a
Oscar Henao Gallo, Universidad Politécnica de Valencia, Valencia. España
PhD, Doctor en Bioingeniería Instituto de Investigación Interuniversitario en Bioingeniería y Tecnología Orientada al Ser Humano, Universidad Politécnica de Valencia, Valencia. España. Pertenece al grupo de Fisiología Celular de la Universidad Tecnológica de Pereira.
Eduardo Ramírez Vallejo, Hospital Universitario San Jorge. Pereira. Colombia
MD, MSc, Profesor Asociado, Facultad de Medicina, Universidad Tecnológica de Pereira. Grupo de Fisiología Celular de la Universidad Tecnológica de Pereira. Unidad de Cardiología y Medicina Interna, Hospital Universitario San Jorge. Pereira. Colombia.
José Maria Ferrero Jr., Universidad Politécnica de Valencia, España
PhD. Doctor en Ingeniería Industrial. Departamento de Electrónica, Universidad Politécnica de Valencia, España.
Jorge Reynolds Pombo
Doctor Ad Honorem en Ingeniería Biomédica, Director Grupo de Seguimiento al Corazón Vía Satélite
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