Interferencia de la infección por rotavirus mediante la inhibición de la actividad de la proteína disulfuro isomerasa (DPI) de la membrana celular de las líneas MA104 y Caco-2.


  • Carlos Arturo Guerrero Fonseca Universidad Nacional de Colombia
  • Martha N. Calderón Universidad Nacional de Colombia
  • Orlando Acosta Losada Universidad Nacional de Colombia
  • Fanny Guzmán Universidad Nacional de Colombia

Palabras clave:

rotavirus, Biología Molecular de virus, virología, gastroenteritis


Los rotavirus son la causa más común de gastroenteritis severa en niños menores de cinco años, ocasionando episodios diarreicos agudos responsables de 454.000 a 705.000 muertes anuales a nivel mundial. Aunque la frecuencia de infección con rotavirus es muy similar a través del mundo, en los países en desarrollo la gastroenteritis rotaviral es la mayor causa de muerte infantil.  La diarrea rotaviral severa cursa con vómito y fiebre, produciendo deshidratación con shock, desbalance electrolítico, y muerte si esta no es tratada. En los países desarrollados, la infección rotaviral es responsable del 30 - 50% de las hospitalizaciones debidas a gastroenteritis en menores de 5 años. Además, los rotavirus son una causa importante en la gastroenteritis nosocomial.   

Biografía del autor/a

Carlos Arturo Guerrero Fonseca, Universidad Nacional de Colombia

Laboratorio de Biologia Molecular de Virus. Facultad de Medicina

Martha N. Calderón, Universidad Nacional de Colombia

Departamento de Ouimica. Facultad de Ciencias

Orlando Acosta Losada, Universidad Nacional de Colombia

Laboratorio de Biologia Molecular de Virus. Facultad de Medicina

Fanny Guzmán, Universidad Nacional de Colombia

Departamento de Ouimica. Facultad de Ciencias

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Cómo citar

Guerrero Fonseca, C.A. et al. 2008. Interferencia de la infección por rotavirus mediante la inhibición de la actividad de la proteína disulfuro isomerasa (DPI) de la membrana celular de las líneas MA104 y Caco-2. Medicina. 30, 4 (dic. 2008), 229–258.


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