Interferencia de la infección por rotavirus mediante la inhibición de la actividad de la proteína disulfuro isomerasa (DPI) de la membrana celular de las líneas MA104 y Caco-2.
Palabras clave:
rotavirus, Biología Molecular de virus, virología, gastroenteritisResumen
Los rotavirus son la causa más común de gastroenteritis severa en niños menores de cinco años, ocasionando episodios diarreicos agudos responsables de 454.000 a 705.000 muertes anuales a nivel mundial. Aunque la frecuencia de infección con rotavirus es muy similar a través del mundo, en los países en desarrollo la gastroenteritis rotaviral es la mayor causa de muerte infantil. La diarrea rotaviral severa cursa con vómito y fiebre, produciendo deshidratación con shock, desbalance electrolítico, y muerte si esta no es tratada. En los países desarrollados, la infección rotaviral es responsable del 30 - 50% de las hospitalizaciones debidas a gastroenteritis en menores de 5 años. Además, los rotavirus son una causa importante en la gastroenteritis nosocomial.Biografía del autor/a
Carlos Arturo Guerrero Fonseca, Universidad Nacional de Colombia
Martha N. Calderón, Universidad Nacional de Colombia
Orlando Acosta Losada, Universidad Nacional de Colombia
Fanny Guzmán, Universidad Nacional de Colombia
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