Avances en el manejo del cáncer de riñón, vejiga y próstata

Autores/as

  • Leonardo Rojas Centro de Tratamiento e Investigación sobre Cáncer (CTIC)
  • Jairo Zuluaga Centro de Tratamiento e Investigación sobre Cáncer (CTIC)
  • Carlos Vargas Fundación para la Investigación Clínica y Molecular Aplicada al Cáncer (FICMAC)

DOI:

https://doi.org/10.56050/01205498.2309

Palabras clave:

Cáncer de próstata, Carcinoma de células renales, Cáncer urotelial, Anticuerpos conjugados con medicamentos, Cáncer de vejiga, Oncología genitourinaria, Inmunoterapia, Terapia radioligando

Resumen

Los tumores genitourinarios son diversos en su cuadro clínico, prevalencia y mortalidad. Ha habido avances significativos en el tratamiento de estos tumores con combinaciones conocidas (p. ej. inhibidores del punto de control inmunitario, inhibidores de la tirosina quinasa), y también con fármacos más nuevos (p. ej. anti-TIGIT, anti-LAG3, belzutifan, enfortumab vedotin y sacituzumab govitecan) y nuevas combinaciones. Han surgido datos sólidos sobre el papel de la inmunoterapia en el carcinoma de células renales y en el cáncer de vejiga y cómo superar la resistencia. Datos recientes aclararon el papel de la intensificación de la terapia de primera línea en el cáncer de próstata sensible a la castración metastásico, específicamente para aquellos con enfermedad de alto volumen. También hay evidencia creciente para el uso de la terapia con radioligandos, con un perfil de seguridad más amplio que inspira nuevas combinaciones de investigación.

Biografía del autor/a

Leonardo Rojas, Centro de Tratamiento e Investigación sobre Cáncer (CTIC)

Unidad Funcional Clínica Urología Oncológica, Centro de Tratamiento e Investigación sobre Cáncer (CTIC) Luis Carlos Sarmiento Angulo, Bogotá, Colombia.

Jairo Zuluaga, Centro de Tratamiento e Investigación sobre Cáncer (CTIC)

Unidad Funcional Clínica Urología Oncológica, Centro de Tratamiento e Investigación sobre Cáncer (CTIC) Luis Carlos Sarmiento Angulo, Bogotá, Colombia.

Carlos Vargas, Fundación para la Investigación Clínica y Molecular Aplicada al Cáncer (FICMAC)

Fundación para la Investigación Clínica y Molecular Aplicada al Cáncer (FICMAC), Bogotá, Colombia.

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Cómo citar

[1]
Rojas, L. et al. 2023. Avances en el manejo del cáncer de riñón, vejiga y próstata. Medicina. 45, 4 (dic. 2023), 672–686. DOI:https://doi.org/10.56050/01205498.2309.

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2023-12-31

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