Modelo para la determinación de los marcadores genéticos de la respuesta inmunitaria en poblaciones colombianas


  • Edmond J. Yunis Dana-Farber Cancer Institute
  • Eduardo Egea Dana-Farber Cancer Institute

Palabras clave:

marcadores genéticos, respuesta inmunitaria, genética, inmunología, sistema inmunitario


Basados en nuestra experiencia, es posible estudiar factores genéticos del complejo mayor de histocompatibilidad (CMH) en varias enfermedades inmunológicas, o también factores genéticos que influyen en la falta de respuesta inmunitaria a vacunas como la hepatitis B. Los alelos de diferentes loci del CMH sirven por sí mismos para identificar riesgos para enfermedades o falta de respuesta a vacunas. El bloque de genes del CMH, que pueden existir al nivel de la población, en desequilibrio de enlace genético, es un mayor marcador para estudiar la susceptibilidad genética a enfermedades como las atopías así como también la falta de respuesta a vacunas. Nosotros proponemos que un estudio inmunogenético de poblaciones colombianas, podría utilizarse como control para identificar susceptibilidad genética para el desarrollo de atopías a los ácaros del polvo y a los hongos (mohos), que son alergenos comunes en Colombia. También, la existencia de una gran susceptibilidad para la hepatitis delta en la región norte de Colombia, indica que un estudio inmunogenético de identificación de haplotipos colombianos asociados con la falta de respuesta a la vacuna contra la hepatitis B serían muy útiles.

La identificación de individuos que no responden a vacunas comunes, sugeriría que ellos son más susceptibles a adquirir la hepatitis. En consecuencia, será necesario desarrollar otras vacunas con diferentes ntígenos para proteger a esa población.

Biografía del autor/a

Edmond J. Yunis, Dana-Farber Cancer Institute

Profesor de Patologia Escuela de Medicina. Universidad de Harvard Boston, MA, U.S.A.
Jefe División de Inmuno-genética, Dana- Farber Cancer Institute. Miembro Honorario

Eduardo Egea, Dana-Farber Cancer Institute

Profesor Facultad de Medicina Universidad del Norte Barranquilla, Colombia. Research Fellow de la División de Inmunogenética, Dana-Farber Cancer Institute.

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Cómo citar

Yunis, E.J. y Egea, E. 1988. Modelo para la determinación de los marcadores genéticos de la respuesta inmunitaria en poblaciones colombianas. Medicina. 10, 19 (ago. 1988), 18–30.


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