LEUCOCITOSIS CON NEUTROFILIA: MÁS ALLÁ DE LA INFECCIÓN

  • Fabricio Andrés Lasso Andrade Universidad del Cauca
  • Diego Fernando Dorado Universidad del Cauca
  • Tomás Omar Zamora Universidad del Cauca

Resumen

El hallazgo de leucocitosis con neutrofilia se ha asociado clásicamente a un origen infeccioso, aunque existen muchas otras condiciones benignas o malignas que pueden producir este hallazgo en el hemograma. Se deben tener en cuenta las causas de pseudoleucocitosis como el agrupamiento de plaquetas por el anticoagulante ácido dietilenediaminotetraacético (EDTA) que se presenta también como una causa de pseutrombocitopenia, además de la pseudoleucocitosis que se presenta en las crioglobulinemias. Existen causas primarias como la neutrofilia hereditaria crónica, trastorno genético que se caracteriza por tener activado el gen del CSF3 (factor estimulante de colonias de granulocitos) produciendo proliferación de neutrófilos, así también en los neonatos con síndrome de Down se presenta un recuento aumentado de leucocitos como parte del Trastorno mieloproliferatio transitorio, que en la mayoría de veces es autolimitado. La leucocitosis con neutrofilia se presenta como un desafío para el médico, dando la imperiosa necesidad de una búsqueda meticulosa de sus causas reales, las cuales pueden ser espurias, primarias o secundarias; el clínico debe basar su aproximación diagnóstica en una adecuada historia clínica y un acucioso examen físico. En ese contexto, la presente revisión narrativa persigue como objetivo dar a conocer las diferentes causas de la leucocitosis con neutrofilia tendiente a describir una aproximación clínica para su abordaje diagnóstico.

Biografía del autor

Fabricio Andrés Lasso Andrade, Universidad del Cauca
MD. Universidad del Cauca, Facultad Ciencias de la Salud. Popayán, Colombia.
Diego Fernando Dorado, Universidad del Cauca
MD. Universidad del Cauca, Facultad Ciencias de la Salud. Popayán, Colombia.
Tomás Omar Zamora, Universidad del Cauca
MD. MSP. Universidad del Cauca, Facultad de Ciencias de la Salud. Popayán, Colombia.

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Publicado
2018-10-07
Sección
Artículos de Revisión